Our research focuses on the genetic background of antibiotic resistant Gram-negative pathogens. We are specifically interested in the characterization of extended-spectrum β-lactamase (ESBL), carbapenemase-producing, and colistin-resistant organisms isolated from humans, animals, food chain and environment (One Health approach). Furthermore, we correlate the phenotypic and genetic background of resistance to the characteristics of patients (e.g., underlying diseases, risk factors, and use of antibiotics) and their clinical outcome under different antimicrobial treatments. We are also interested on the: i) development of novel antimicrobial therapies (including those based on bacteriophages) against multidrug-resistant Gram-negatives, and ii) development of new strategies and novel techniques to speed up the diagnosis of serious infections due to multidrug-resistant Gram-negatives.
Collaborative proposals should be submitted to Dr. Endimiani via email